Journal
PARASITE IMMUNOLOGY
Volume 39, Issue 10, Pages -Publisher
WILEY
DOI: 10.1111/pim.12460
Keywords
allergy; atopy; asthma; Fasciola hepatica; immune modulation
Categories
Funding
- Science Foundation Ireland [11/PI/1036, 12/RI/2340 (7)]
- Science Foundation Ireland (SFI) [12/RI/2340 (7)] Funding Source: Science Foundation Ireland (SFI)
Ask authors/readers for more resources
There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica (FHES) protected mice against ovalbumin (OVA)-induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen-challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways. Interestingly, systemic administration of FHES at allergen challenge had no effect on airway inflammation, demonstrating that alum-induced Th2 response is set following initial allergen sensitization. Our findings highlight the immunomodulatory potential of molecules secreted by F.hepatica.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available