Journal
HELIYON
Volume 4, Issue 8, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2018.e00737
Keywords
Materials science
Categories
Funding
- NIH-NIGMS [1SC3GM121229]
- Welch Foundation
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Therapeutic drug delivery systems using polymeric materials is an emerging field of research. However, the use of certain polymers has gained much-needed attention by the researchers due to their low toxic nature. In recent years, chitosan has gained popularity as a potential biodegradable polymer that can be used as a component in drug delivery systems. In this study, we synthesized a chitosan derivative that is composed of both folic acid and zinc and may serve as a viable component of a drug delivery system. The results of Fourier Transform Infrared Spectroscopy ( FTIR), solid-state C-13 Nuclear Magnetic Resonance Spectroscopy (NMR) and UV-visible Spectroscopy demonstrated a substantial difference between chitosan and ZnS/Chitosan-Folic acid derivative. The results were also confirmed using Thermogravimetric Analysis (TGA) and Scanning Electron Microscopy/Energy Dispersive X-ray Spectroscopy (SEM-EDS) techniques. The average particle size of the ZnS/Chitosan-Folic acid system was measured to be 463.67 +/- 5.76 nm, showing that the product is within the nano-size range.
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