Journal
PAEDIATRIC RESPIRATORY REVIEWS
Volume 23, Issue -, Pages 27-32Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.prrv.2016.11.003
Keywords
Infants; Lung; prematurity; pulmonary hypertension; risk factors; Bronchopulmonary dysplasia; echocardiography; chronic lung disease
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Objectives: Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk for development of Pulmonary Hypertension (PHT). We performed a systematic review and meta-analysis to identify risk factors for development of PHT in infants with BPD. Study Design: A systematic review identified risk factors for the development of PHT in infants with BPD. A meta-analysis of the pooled data was performed for each individual risk factor. Result: Of the 20 risk factors identified, 10 were repeated more than once in nine studies. Meta analysis showed that duration of mechanical ventilation, length of stay, oligohydramnios, use of high frequency ventilation, small for gestational age, sepsis and severity of BPD were significant risk factors; while birth weight and gestational age were inversely related. Conclusion: Several clinical variables are predictive of the development of PHT in infants with BPD. Prospective studies are needed to transform these risk factors into a risk-based scoring system. (C) 2016 Published by Elsevier Ltd.
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