Journal
ACS OMEGA
Volume 3, Issue 8, Pages 8980-8991Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b01310
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Funding
- Natural Science and Engineering Research Council (NSERC) in Canada
- Canada Research Chair (CRC) Award
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We report new dual acidic pH/reduction responsive degradable amphiphilic block copolymers featured with dual acidic pH-labile acetal linkage and a reductively-cleavable disulfide bond at the hydrophilic/hydrophobic block junction as well as pendant disulfide bonds in the hydro phobic block. Centered on the use of a macroinitiator approach, three strategies utilize the combination of atom transfer radical polymerization and reversible addition fragmentation chain transfer, polymerization in a sequential or concurrent mechanism, along with facile coupling reactions. Combined structural analysis with dual-stimuli-responsive degradation investigation allows better under standing of the architectures and orthagonalities of the farmed block copolymers as a diblock or a triblock copolymer. Our study presents the development of effective synthetic strategies to well-defined multifunctional amphiphilic block copolymers that exhibit dual-stimuli-responsive degradation at dual location (called the DL-DSRD strategy), thus potentially promising as nanoassemblies for effective drug delivery.
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