Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 5, Issue 5, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1023929
Keywords
intercellular DNA transfer; mitochondrial DNA deletion; metastasis; respiration; tumor growth
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Funding
- Malaghan Institute
- Australian Research Council
- Czech Science Foundation [P301/10/1937]
- BIOCEV European Regional Development Fund [CZ.1.05/1.1.00/02.0109]
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Horizontal gene transfer is known to occur in bacteria and archaea whereas higher organisms including mammals undergo vertical transfer. Our recent results demonstrate horizontal transfer of mitochondrial DNA (mtDNA) from normal host cells to tumor cells lacking mitochondrial DNA (mtDNA). This mtDNA migration results in recovery of respiration, restored tumor initiation, and metastasis.
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