Journal
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
Volume 50, Issue 1, Pages 13-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.otc.2016.08.009
Keywords
Chronic rhinosinusitis; Chronic rhinosinusitis with nasal polyps; Chronic rhinosinusitis without nasal polyps; Genetics; Single -nucleotide polymorphisms; Immune dysregulation; Primary immunodeficiency
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Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically and surgically, a significant proportion of patients has a refractory form of CRS despite maximal therapy. Two of the several described factors thought to contribute to disease recalcitrance are genetic influences and dysfunction of the host immune system. Current evidence for a genetic basis of CRS is reviewed, as it pertains to putative abnormalities in innate and adaptive immune function. The role of systemic immunodeficiencies in refractory CRS is discussed.
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