Journal
JOURNAL OF RESEARCH IN PHARMACY
Volume 22, Issue 3, Pages 460-468Publisher
MARMARA UNIV
DOI: 10.12991/jrp.2018.88
Keywords
Salbutamol; boron-doped diamond electrode; square-wave adsorptive stripping voltammetry; pharmaceutical formulations
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This paper examined for the first time the possibilities of the usage of the cathodically pretreated borondoped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 mu g mL(-1) (1.73x10(-5) -3.47x10(-4) M). A detection limit of 1.21 mu g mL(-1) (5.06x10(-6) M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.
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