Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 21, Issue 11, Pages 1843-1850Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.7b00291
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Funding
- National Natural Science Foundation of China [U1608221, U1662124]
- CAS [2017229]
- MOST innovation team in key area [2016RA4053]
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In this work, continuous flow nitration of trifluoromethoxybenzene-(TFMB) was conducted in a microchannel reactor. The effects of process parameters, including temperature, residence tine, sulfuric acid strength, flow rate, and reactor structure, were systemically investigated. It was found that the aforementioned process parameters had significant effect on TFMB conversion, while the product selectivity was merely sensitive to the reaction temperature. On the basis of the results of process parameter optimization, a scale-up strategy combining microreactor with distributed packed tubular reactor was presented. Consequently, excellent performance was achieved in the combined. reactor with a kilogram-scale production.
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