Journal
2ND BIOMEDICAL ENGINEERINGS RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES
Volume 1933, Issue -, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.5023989
Keywords
bioreactor; biomimetic; cell stimulation; engineered micro ecosystem; neural stem cell
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Funding
- Ministry of Research, Technology, and Higher Education of Republic of Indonesia in year 2016-2017
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Bioreactor provides a biomimetic ecosystem that is able to culture cells in a physically controlled system. In general, the controlled-parameters are temperature, pH, fluid flow, nutrition flow, etc. In this study, we develop a bioreactor that specifically targeted to culture neural stem cells. This bioreactor could overcome some limitations of conventional culture technology, such as petri dish, by providing specific range of observation area and a uniform treatment. Moreover, the microfluidic bioreactor, which is a small-controlled environment, is able to observe as small number of cells as possible. A perfusion flow is applied to mimic the physiological environment in human body. Additionally, this bioreactor also provides an electrical stimulation which is needed by neural stem cells. In conclusion, we found the correlation between the induced shear stress with geometric parameters of the bioreactor. Ultimately, this system shall be used to observe the interaction between stimulation and cell growth.
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