Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 21, Issue 10, Pages 1588-1594Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.7b00229
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Funding
- EPSRC [EP/K009494/1, EP/M004120/1, EP/K039520/1]
- Syngenta Crop Protection AG
- EPSRC [EP/K039520/1, EP/M004120/1, EP/K009494/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M004120/1, EP/K009494/1, EP/K039520/1] Funding Source: researchfish
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We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h(-1) of DBFO.
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