4.8 Article

Iridium(III)-Catalyzed Synthesis of Benzimidazoles via C-H Activation and Amidation of Aniline Derivatives

Journal

ORGANIC LETTERS
Volume 19, Issue 12, Pages 3243-3246

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01356

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Funding

  1. NSFC [21525208, 21472186]
  2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences

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Ir(III)-catalyzed synthesis of benzimidazoles has been realized under redox-neutral conditions by annulation of aniline derivatives with dioxazolones. The reaction proceeded via a C-H activation-amidation-cyclization pathway with a decent substrate scope.

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