4.8 Article

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond

Journal

ORGANIC LETTERS
Volume 19, Issue 14, Pages 3723-3726

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01549

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Funding

  1. National Natural Science Foundation of China [21172208]
  2. National Basic Research Program of China [2015CB856600]

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Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-O-Py bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions.

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