Journal
ORGANIC LETTERS
Volume 19, Issue 21, Pages 5972-5975Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02983
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Funding
- NSFC [21525208, 21472186]
- fund for new technology of methanol conversion of Dalian Institute of Chemical Physics (Chinese Academy of Sciences)
- Chinese Academy of Sciences [XDB17020300]
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An efficient synthesis of disubstituted acrylic acids has been realized via Rh(III)-catalyzed C-H activation of (hetero)arenes and coupling with four-membered methyleneoxetanones under redox-neutral conditions. In most cases, the reactions are silver-free, and the products are exclusively E-selective with a broad substrate scope. The transformation proceeds via ortho C-H activation followed by selective olefin insertion and beta-oxygen elimination.
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