Journal
ORGANIC LETTERS
Volume 19, Issue 20, Pages 5661-5664Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02823
Keywords
-
Categories
Funding
- PCSIRT [IRT 1231]
- Natural Science Foundation of China [21376058]
- Major Scientific and Technological Innovation Projects of Hangzhou City [20162011A036]
Ask authors/readers for more resources
The first example of nickel(II)-catalyzed site-selective C-H bond trifluoromethylation of arylamine in water is established. In this transformation, a coordinating activation strategy is performed by the utilization of picolinamide as a directing group, and target products are obtained in moderate to good yields. In addition, the catalyst-in-water system can be reutilized eight times with a slight loss of catalytic activity and applied in the green, concise synthesis of acid red 266. Furthermore, a series of control experiments verify that a single-electron transfer mechanism is responsible for this reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available