Journal
ORGANIC LETTERS
Volume 19, Issue 17, Pages 4676-4679Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02316
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Funding
- National Natural Science Foundation of China [21332005, 21472085, 21672100]
- Fundamental Research Funds for the Central Universities [020514380114]
- Robert A. Welch Foundation (USA) [D-1361]
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Catalytic oxidative cross-dehydrogenative coupling between unactivated C(sp(2))-H and C(sp(3))-H bonds is achieved by the cobalt-catalyzed o-alkylation reaction of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine (PIP-NH2) as a N,N-bidentate directing group. Many different C(sp(3))-H bonds in alkanes, toluene derivatives and even in the alpha-position of ethers and thioethers can be used as coupling partners. This method has a broad substrate scope and the tolerance of various functional groups.
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