4.8 Article

Phosphinoyl Radical Initiated Vicinal Cyanophosphinoylation of Alkenes

Journal

ORGANIC LETTERS
Volume 19, Issue 20, Pages 5537-5540

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02621

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Funding

  1. National Natural Science Foundation of China [21172163, 21472133]
  2. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
  3. State, and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials

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A double-functionalization reaction of alkenes through Mn-(OAc)(3)-mediated phosphinoyl radical addition followed by CuCN-catalyzed cyanation is introduced. This one-pot reaction is performed under mild conditions to afford vicinal cyanophosphinoylation products.

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