Journal
ORGANIC LETTERS
Volume 19, Issue 9, Pages 2446-2449Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01085
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- Chinese University of Hong Kong [4053199]
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Hydroxytrifluoromethylation of alkenes using the fluoroform (CF3H)-derived [CuCF3] reagent is, described. In the presence of additive B(2)Pin(2) and air, this reagent effectively facilitates the addition of hydroxy and trifluoromethyl groups across an alkene double bond, a formal hydroxyttifluoromethylation process. Various beta-trifluoromethyl alcohols can be synthesized from simple alkenes where the ultimate CF3 source is the industrial byproduct fluoroform.
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