Diastereoselective Radical Oxidative C-H Aminations toward Chiral Atropoisomeric (P, N) Ligand Precursors

A new class of chiral atropoisomeric (P, N) ligand precursors has been obtained with excellent diastereoselectivities and high yields through diastereoselective metal free intramolecular radical oxidative C-H amination with chiral phosphamide as the auxiliary group. This method provides a concise and highly valuable pathway for the synthesis of enantiopure aminophosphine ligands in largescale.