Journal
ORGANIC LETTERS
Volume 20, Issue 1, Pages 240-243Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03600
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Funding
- Institute for Basic Science [IBS-R010-G1]
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A straightforward synthetic strategy to construct biologically relevant phenanthridinones and quinolinones was developed via visible-light-promoted direct oxidative C-H amidation. In this photocatalytic system, amidyl radicals can be generated by homolysis of the N-H bond of simple amide precursors via single-electron transfer under blue LED illumination, which leads to oxidative intramolecular C-H amidation. Moreover, an efficient synthetic strategy using a photocascade enabled facile assembly of quinolinone structures through a catalytic sequence involving triplet energy (E-T) transfer based E/Z olefin isomerization and subsequent photocatalytic generation of amidyl radical intermediates.
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