Journal
ORGANIC LETTERS
Volume 19, Issue 15, Pages 4046-4049Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01803
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Funding
- Chemical Industry Fund (FCI Liebig-fellowship)
- LMU, Munich
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Alkylidenecyclobutanes (ACBs) containing all carbon quaternary stereocenters were simply and efficiently synthesized by combining boron-homologation and gamma-selective cross-coupling strategies. This unique sequence led to excellent regio- and diastereoselectivities in the generation of targeted four-membered rings with up to 99% enantiomeric excess using chiral substrates. In addition to the original synthesis of ACBs, the first asymmetric catalytic formation of quaternary stereocenters based on gamma-selective cross-coupling reactions is finally shown.
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