Journal
ORGANIC LETTERS
Volume 19, Issue 5, Pages 1160-1163Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00200
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Funding
- National Natural Sciences Foundation of China [21472017]
- Natural Sciences Foundation of Jilin Province [20150101065JC]
- Education Department of Jilin Province
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A new strategy for direct and highly efficient synthesis of 2,3'-bisindolin-3-ones has been developed via a gold/copper-co-catalyzed tandem reactions of 2-alkynylanilines using TBHP as the terminal oxidant and oxygen-atom source. The single-step process involves a novel tandem intermolecular nucleophilic addition, intramolecular cyclization/oxidative cross-dehydrogenative coupling where up to four new bonds and two indole rings were created simultaneously in one-pot manner. The reaction features a broad substrate scope, good functional group tolerance, and high atom-economy.
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