4.8 Article

Chiral Selenide-Catalyzed Enantioselective Construction of Saturated Trifluoromethylthiolated Azaheterocycles

Journal

ORGANIC LETTERS
Volume 19, Issue 13, Pages 3434-3437

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01392

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Funding

  1. Sun Yat-Sen University
  2. One Thousand Youth Talents Program of China
  3. Natural Science Foundation of Guangdong Province [2014A030312018]

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An indane-based, bifunctional, chiral selenide catalyst has been developed. The new catalyst is efficient for the enantioselective synthesis of saturated azaheterocycles possessing a trifluoromethylthio group. The desired products were obtained in good yields with high diastereo- and enantioselectivities.

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