Journal
ORGANIC LETTERS
Volume 19, Issue 18, Pages 4988-4991Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02502
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Funding
- National Natural Science Foundation of China [21532006, 21690074]
- Strategic Priority Program of Chinese Academy of Sciences [XDB17020300]
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By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee. This method avoids tedious steps of installation and removal of the activating groups. The mechanism studies indicated that hydrogen halide generated in situ acted as an activator of isoquinolines and pyridines.
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