Journal
ACS OMEGA
Volume 3, Issue 9, Pages 10886-10890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b01426
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Funding
- NIMH [R01 107499-01A1]
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A rapid, transition metal-free, high-yielding, tetrabutylammonium bromide-promoted method of N-arylation is reported within. The optimized conditions tolerated a wide range of secondary amines and was equally effective with bromo-and chlorobenzene-including substituted aryl halides. The developed method is found to be effective for N-arylation when compared to earlier methods which involve harsh conditions, transition metals, lack of scalability, and long reaction times. Our method utilizes conventional heating only; it is readily scalable; and the products are facile to purify.
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