Chemical Synthesis of Biosurfactant Succinoyl Trehalose Lipids

Herein, we report, for the first time, a strategy to differerttiate O4/O4' positions of 1,1'-alpha,alpha-trehalose via, regioselective protection or site-selective functionalization and its application in. the first chemical synthesis, of succinoyl trehalose lipids. The biosurfactant glycolipids were obtained in 11-12 steps starting from trehalose in time span of 8=10 days and 11-12% overall yields.