Journal
ORGANIC LETTERS
Volume 19, Issue 12, Pages 3323-3326Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01504
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Funding
- National Natural Science Foundation of China [21372017, 21402003, 21290183, 21572008]
- State Key Laboratory of Drug Research
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A new approach for the divergent total synthesis of eight ergot alkaloids is reported. The approach allows the first total syntheses of pyroclavine, pibocin A, 9-deacetoxyfumigaclavine C, and fumigaclavine G and also enables the efficient synthesis of festuclavine, costaclavine, epi-costaclavine, and dihydrosetoclavine. The main feature of the synthesis is the use of an unprecedented Pd-catalyzed intramolecular Larock indole annulation/TsujiTrost allylation cascade to assemble the tetracyclic core in one step.
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