Journal
ORGANIC LETTERS
Volume 19, Issue 23, Pages 6396-6399Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03252
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Funding
- EPSRC Centre for Doctoral Training in Sustainable Chemistry [EP/L015633/1]
- EPSRC [EP/J021008/1]
- EPSRC [EP/J021008/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J021008/1] Funding Source: researchfish
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The iron(III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity.
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