4.6 Article

Weak Base-Promoted Lactamization under Microwave Irradiation: Synthesis of Quinolin-2(1H)-ones and Phenanthridin-6(5H)-ones

Journal

ACS OMEGA
Volume 3, Issue 9, Pages 12114-12121

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b01742

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Funding

  1. National Strategic Project-Fine Particle of the National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT)
  2. Ministry of Environment (ME)
  3. Ministry of Health and Welfare (MOHW) [2017M3D8A1090658]

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Quinolin-2(1H)-ones and phenanthridin-6(5H)-ones are synthesized in high yields by K2CO3-promoted cyclization of N-aryl-beta-bromo-alpha,beta-unsaturated amides and N-aryl-2-bromobenzamides in dimethyl-formamide under microwave irradiation.

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