4.8 Article

Nickel-(II)-Catalyzed N-Formylation and N-Acylation of Amines

Journal

ORGANIC LETTERS
Volume 19, Issue 8, Pages 2078-2081

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00660

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Funding

  1. Baburaoji Gholap Research Center

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A highly efficient protocol of Ni(II) metal complex, [Ni(quin)(2)], catalyzing N-formylation and N-acylation of amines with moderate to excellent yields, using N,N-dimethylformamide and N,N-dimethylacetamide in the presence of imidazole, is described here. The protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines.

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