Journal
ORGANIC LETTERS
Volume 19, Issue 21, Pages 5744-5747Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02624
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Funding
- NSF [CHE-1301343]
- NIH shared instrument grant [S10OD012077]
- Mellichamp Academic Initiative in Sustainability
- China Scholarship Council
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By using designed biphenyl-2-ylphosphines functionalized with a remote basic groups as ligands, N-alkynyl-o-nosylamides are directly converted to (1E,3E)-1-amido-1,3-dienes with excellent diastereoselectivities under gold catalysis. With allenamides as substrates, the gold-catalyzed isomerizations are high yielding and applicable to a broad substrate scope including various nitrogen protecting groups and exhibit unprecedented (3E)-selectivities for the distal C-C double bond and good regioselectivities. Combining this gold catalysis with one-pot Diels-Alder reactions leads to rapid assembly of valuable bicyclic compounds.
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