4.8 Article

From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation

Journal

ORGANIC LETTERS
Volume 19, Issue 23, Pages 6432-6435

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03337

Keywords

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Funding

  1. National Natural Science Foundation of China [21390400, 21520102003, 21272180, 21302148]
  2. Hubei Province Natural Science Foundation of China [2013CFA081]
  3. Research Fund for the Doctoral Program of Higher Education of China [20120141130002]
  4. Ministry of Science and Technology of China [2012YQ120060]
  5. Program of Introducing Talents of Discipline to Universities of China (111 Program)

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A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.

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