Journal
ORGANIC LETTERS
Volume 19, Issue 12, Pages 3095-3098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01199
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Funding
- Rutgers University
- NSF-MRI grant [CHE-1229030]
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Transition-metal-catalyzed cyanation of aryl halides is' a process of significant importance in the preparation pharmaceuticals, organic materials and agrochemicals. Here, we demonstrate a palladium-catalyzed decarbonylative cyanation of amides by highly selective carbon nitrogen bond cleavage for the synthesis of a wide range aryl nitriles. The utility of this technology is demonstrated by the synthesis of isotopically labeled aryl nitriles and orthogonal cross-coupling reactions of bench-stable amides, to establish cross-coupling synthons with opposite polarity.
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