4.8 Article

Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

Journal

ORGANIC LETTERS
Volume 19, Issue 12, Pages 3091-3094

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01194

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Funding

  1. DAAD for a doctoral fellowship

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A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a Straightforward and mild fashion.

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