Journal
ORGANIC LETTERS
Volume 19, Issue 9, Pages 2426-2429Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00989
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Funding
- NIGMS [R01 GM-113878]
- Bengt Lundqvist Foundation (Swedish Chemical Society)
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An electrophilic, imide-based, visible-light promoted photoredox/Ni-catalyzed cross-coupling reaction for the synthesis of aliphatic ketones has been developed. This protocol proceeds through N-C(O) bond activation, made possible through the lower activation energy for metal insertion into this bond due to delocalization of the lone pair of electrons on the nitrogen by electron-withdrawing groups. The operationally simple and mild cross-coupling reaction is performed at ambient temperature and exhibits tolerance for a variety of functional groups.
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