Journal
ORGANIC LETTERS
Volume 19, Issue 23, Pages 6364-6367Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03213
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Funding
- National Natural Science Foundation of China [21225208, 21472137, 21532008]
- National Basic Research Program of China (973 Program) [2014CB745100]
- Tianjin Municipal Science AMP
- Technology Commission [14JCZDJC33400]
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A catalytic enantioselective Mukaiyama-Mannich reaction of cyclic C-acylimines with difluoroenoxysilanes is reported.(S)-TRIP enables the enantioselective synthesis of a series of novel difluoroalkylated indolin-3-ones bearing a quaternary stereocenter in up to 97% yield and 98% ee. The synthetic utility of this protocol is highlighted by efficient conversion of the products to the corresponding indolin-3-one derivatives without any erosion of the enantiopurity.
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