Journal
ORGANIC LETTERS
Volume 19, Issue 7, Pages 1686-1689Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00476
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Funding
- National Natural Science Foundation of China [31672078]
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Histone deacetylation normally decreases the gene expression in organisms. By genome-wide deletions of epigenetic regulators in entomopathogenic fungus Metarhizium robertsii unexpected activations of orphan secondary metabolite genes have been found upon the disruption of a histone acetyltransferase (HAT) gene Hat1. This led to the characterization of 11 new natural products, including eight isocoumarin derivatives meromusides A-H and two nonribosomal peptides meromutides A and B. Therefore, disruption of HAT represents a new approach to mine chemical diversity from fungi.
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