Ambient-Light-Promoted Three-Component Annulation: Synthesis of Perfluoroalkylated Pyrimidines

An ambient-light-promoted and,metal-free three-component reaction of active methylene compounds perfluoroalkyl iodides, and guanidines/amidines is reported: This constitutes a powerful method to prepare prfluoroalky-lated pyrinudines with mild reaction Conditions, broad substrate scope, excellent functional group tolerance, and simple operation. A radical/polar mechanism involving the formation of a halogen-bond adduct and radical cross-coupling is proposed.