Journal
ORGANIC LETTERS
Volume 20, Issue 1, Pages 119-121Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03555
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Funding
- JSPS KAKENHI [26713001, 16H01141, 17H01523]
- Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research
- BINDS) from the Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [16H01141, 17H01523] Funding Source: KAKEN
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A total synthesis of huperzine R was accomplished. Intramolecular cycloaddition of a nitrile oxide and reductive cleavage of the resulting isoxazoline induced Me sequential cleavage of the C-C and C-O bonds to form the characteristic bicyclic lactam core with an enone moiety. Construction of the butenolide moiety from the enone afforded huperzine R.
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