Journal
ORGANIC LETTERS
Volume 19, Issue 8, Pages 2138-2141Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00776
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Funding
- National Natural Science Foundation of China [21325209, 21472205, 81521005]
- Shanghai Municipal Committee of Science and Technology [14xd1404400]
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With the use of a simple sulfur olefin ligand, a highly enantioselective rhodium-catalyzed addition of arylboroxines to N,N-dimethylsulfamoyl-protected aldimines has been achieved; allowing access to a broad range of chiral diarylmethylamines in high yields (up to 98%) with uniformly excellent enantioselectivities (up to 99% ee). This catalyst system is also applicable to the arylation of N-tosyl arylimines. By utilizing this method, some biologically active molecules possessing a chiral 1-ary1-1,2,3,4-tetrahydroisoquinoline core such as Solifenacin and (S)-(+)-Cryptostyline II are facilely constructed.
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