Journal
ORGANIC LETTERS
Volume 19, Issue 24, Pages 6490-6493Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03085
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Funding
- NWO VENI grant
- ERC grant
- MRC [MC_U105192732] Funding Source: UKRI
- Medical Research Council [MC_U105192732] Funding Source: researchfish
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An optimized large scale and highly reproducible route to orthogonally protected gamma-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic polyubiquitin chains of defined linkage.
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