Journal
ORGANIC LETTERS
Volume 19, Issue 19, Pages 5304-5307Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02601
Keywords
-
Categories
Funding
- Russian Science Foundation [17-13-01041]
- Russian Science Foundation [17-13-01041] Funding Source: Russian Science Foundation
Ask authors/readers for more resources
A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in situ generated difluorinated phosphorus ylide Ph3P = CF2. Aromatic acids can be selectively transformed within one step either to bis-difluoromethylated alcohols or to difluorinated ketones depending on the particular reaction conditions. For bulky alpha-branched carboxylic acids, only ketones are produced.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
