Total Synthesis and Structural Revision of Aeruginosin KT608A

The synthesis of the presumed structure of aeruginosin KT608A Was accomplished for:the first time. The unusual D-diepi-Choi core was prepared from tyrosine via C-H activation and heterogeneous hydrogenation. Due to differences in the spectral data of synthetic and natural Samples, a revised structure featuring L-diepi-Choi Was proposed, which was synthesized and confirmed to be identical. the basis of these findings; revised Structures: for: six additional aeruginosins (KT608B, KT650, GH553, DA495A, DA511, and K13676) are presented: