4.8 Article

Copper-Catalyzed Imidovinylation of Alkynes via 1,3-Vinyl Migration

Journal

ORGANIC LETTERS
Volume 19, Issue 14, Pages 3767-3770

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01599

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Funding

  1. National NSF of China [21372041]
  2. Changbai Mountain Scholarship Program
  3. Fundamental Research Funds for the Central Universities [2412016KJ006]

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The first copper-Catalyzed imidovinylation of alkyries has been developed, which grants facile access to various (E)-2-imido-2,4-dienals with high stereoselectivity under mild conditions. This transformation also represents the first 1,3-carbon migration Of propargylic alcohols and their derivatives.

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