Journal
ORGANIC LETTERS
Volume 19, Issue 13, Pages 3624-3627Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01591
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Funding
- Ministry of Science and Higher Education (Poland) [DI2012 024842, IP2014 022273]
- National Science Centre, Poland [UMO-2016/21/B/ST5/02556]
- ERDF within the Innovation Economy Operational Programme [POIG.02.01.00-14-122/09]
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Commercially available 2'-O-pivaloyloxymethyl (PivOM) phosphoramidites were employed in an SPS protocol for RNA 5' azides. The utility of the N-3-RNAs in CuAAC and SPAAC was demonstrated by RNA 5' labeling, chemical ligation including fragment joining and cyclization, and bioconjugation. As a result, several new RNA conjugates that may be valuable tools for studies on biological events such as innate immune response (cyclic dinucleotides), post-transcriptional gene regulation (circular RNAs), or mRNA turnover (m(7)G capped RNAs) were obtained.
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