Journal
ORGANIC LETTERS
Volume 19, Issue 13, Pages 3446-3449Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01421
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A highly diastereoselective alpha-arylation of cyclic nitriles has been developed via a Negishi cross-coupling of commercially available aryl, heteroaryl, and alkenyl halides with cyclobutyl nitriles in the presence of tetramethylpiperidinylzinc chloride lithium chloride (TMPZnCl center dot LiCl) and catalytic XPhos-Pd-G2. A variety of electronically diverse electrophiles were well tolerated, and this chemistry was further advanced with application of both cyclopropyl and cyclopentyl nitriles.
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