Journal
ORGANIC LETTERS
Volume 19, Issue 12, Pages 3211-3214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01333
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Funding
- NSFC [21432003, 81473095, 21602091]
- Program for Chang-jiang Scholars and Innovative Research Team in University (PCSIRT) [IRT_15R27]
- Special Research Found for the Doctoral Program of Higher Education [20130211130005]
- Fundamental Research Funds for the Central Universities [lzujbky-2015-282, lzujbky-2016-ct01]
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A magnesium-catalyzed asymmetric ring-opening reaction of aziridines with substituted tetrazoles is reported. The current protocol proceeds smoothly and gives the corresponding desymmetrization products in high yields and good enantioselectivities. A new chiral ligand was synthesized from azetidine and (R)-BINOL and was employed in the current in situ generated magnesium catalyst. The Mg(II)-mediated desymmetrization reaction could be performed on gram scale under mild conditions and was transformed to chiral alkyl amines by a deprotection process.
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