Journal
ORGANIC LETTERS
Volume 19, Issue 22, Pages 6180-6183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03098
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Funding
- ANBG (Agence Nationale des Bourses du Gabon) [828988C]
- French ANR grant [ANR-15-CE29-0001]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE29-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain
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