Journal
ORGANIC LETTERS
Volume 19, Issue 17, Pages 4608-4611Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02219
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Funding
- MSMT [20-SVV/2016]
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The first high-yielding route to arylated 2H-pyrroles was developed. The methodology utilizes 2,5-disubstituted pyrroles that are metalated, and the aryl substituents are introduced by a palladium-catalyzed cross coupling reaction. The prepared pyrroles can be rearranged to 2,3,5-trisubstituted pyrroles under acidic conditions. Attempts to convert the 2,3,5-trisubstituted pyrroles to 2,3,4,5-tetrasubstituted pyrroles by the dearomatization rearrangement strategy were unsuccessful.
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