4.8 Article

Addition of N-Heterocyclic Carbene Catalyst to Aryl Esters Induces Remote C-Si Bond Activation and Benzylic Carbon Functionalization

Journal

ORGANIC LETTERS
Volume 20, Issue 2, Pages 333-336

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03544

Keywords

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Funding

  1. National Natural Science Foundation of China [21472028]
  2. National Key Technologies RD Program [2014BAD23B01]
  3. Thousand Talent Plan
  4. 10 Talent Plan (Shicengci) of Guizhou Province
  5. Guizhou Province Returned Oversea Student Science and Technology Activity Program
  6. Guizhou University (China)
  7. Singapore National Research Foundation [NRF-NRFI2016-06]
  8. Ministry of Education of Singapore [MOE2013-T2-2-003, MOE2016-T2-1-032, RG108/16]
  9. A*STAR Individual Research Grant [A1783c0008]
  10. Nanyang Technological University

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Through the incorporation Of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be, activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp(3)-carbons of aryl carboxylic esters.

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