Journal
ORGANIC LETTERS
Volume 19, Issue 14, Pages 3799-3802Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01427
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Funding
- China NSFC [21372055, 21472030, 21672047]
- SKLUWRE [2018DX02]
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A mild, metal-free, and absolutely para-selective bromination of aniline derivatives has been developed in, excellent yields, wherein the organic dye Eosin Y is employed as The bromine source in company with Selectfluor. Neither air nor moisture sensitive, this facile reaction proceeds smoothly at room temperature and completes Within a short time. Mechanistic studies indicate a radical pathway; therefore, the existence of an in situ generated brominating reagent, Selectbrom, is postulated, which may reasonably account for the unique regioselectivity for the para-bromination of N-acyl- as well as N-sulfonylanilines.
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